- Title
- Individualised medicine: why we need Bayesian dosing
- Creator
- Donagher, Joni; Martin, Jennifer H.; Barras, Michael A.
- Relation
- Internal Medicine Journal Vol. 47, Issue 5, p. 593-600
- Publisher Link
- http://dx.doi.org/10.1111/imj.13412
- Publisher
- Wiley-Blackwell Publishing
- Resource Type
- journal article
- Date
- 2017
- Description
- Individualised drug dosing has been shown to improve patient outcomes and reduce adverse drug events. One method of individualised medicine is the Bayesian approach, which uses prior information about how the population responds to therapy, to inform clinicians about how a specific individual is responding to their current therapy. This information is then used to make changes to the dose. Studies using a Bayesian approach to adjust drug dosing have shown that clinicians are able to achieve a therapeutic range quicker than standard practice. If concentration is related to a pharmacodynamic end-point, this means that the drug will be more effective, and the side-effects will be minimised. Unfortunately, the software options to assist with Bayesian dosing in Australia are limited. The aims of this article are to demystify the concepts of Bayesian dosing, set the context of the Bayesian approach using reference to other dosing strategies and discuss its benefits over current dosing methods for a number of drugs. The article is targeted to medical and pharmacy clinicians, and there is a practical clinical case to demonstrate how this method could be used in everyday clinical practice.
- Subject
- individualised drug dosing; Bayesian; medicine; patient outcomes
- Identifier
- http://hdl.handle.net/1959.13/1351360
- Identifier
- uon:30694
- Identifier
- ISSN:1445-5994
- Rights
- This is the peer reviewed version of the following article: Donagher, J., Martin, J. H. and Barras, Michael A. (2017). Individualised medicine: why we need Bayesian dosing. Internal Medicine Journal, 47(5), pp. 593-600, which has been published in final form at http://dx.doi.org/10.1111/imj.13412. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
- Language
- eng
- Full Text
- Reviewed
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